Methylboronic Acid-d3

Base Information

• Chemical Name: Methylboronic Acid-d3
• CAS No.: 1332481-37-4
• Molecular Formula: CH₅BO₂
• Molecular Weight: 62.8367
• Mol file: 1332481-37-4.mol

Synonyms:(methyl-d₃)boronic acid

Chemical Property of Methylboronic Acid-d3

Chemical Property:

• Melting Point: 87-91°C
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Methylboronic Acid-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Isotope labelled Methylboronic Acid is an methylated derivative of boronic acid, an building block towards various intermediates in suzuki coupling.

Technology Process of Methylboronic Acid-d3

There total 1 articles about Methylboronic Acid-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + methyl-d3-magnesium iodide (41251-37-0) → (methyl-d3)boronic acid (1332481-37-4)

Guidance literature:

Trimethyl borate; methyl-d3-magnesium iodide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 2.16667h;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

Reference yield: 92.0%

5-bromo-N-phenyl-(1H)-pyridin-2-one + (methyl-d3)boronic acid (1332481-37-4) → 5-(methyl-d3)-1-phenylpyridin-2(1H)-one (1093951-85-9)

Guidance literature:

With palladium diacetate; potassium carbonate; ruphos; In water; toluene; at 87 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c7gc01740e

Reference yield:

(methyl-d3)boronic acid (1332481-37-4) + 2-(2-bromo-4,6-dichlorobenzyl)isoindoline-1,3-dione (1448336-43-3) → 2,4-dichloro-6-methyl-D3-benzylamine (1448336-68-2)

Guidance literature:

(methyl-d₃)boronic acid; 2-(2-bromo-4,6-dichlorobenzyl)isoindoline-1,3-dione; With potassium phosphate; palladium diacetate; triphenylphosphine; In diethyl ether; water; toluene; at 80 ℃; for 120h;

With hydrazine hydrate; In ethanol; at 20 ℃; for 0.5h;

upstream raw materials:

Trimethyl borate

methyl-d3-magnesium iodide

Downstream raw materials:

2,4-dichloro-6-methyl-D₃-benzylamine

5-(methyl-d3)-1-phenylpyridin-2(1H)-one

Refernces

• 1、 -. "HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS". Page/Page column 64. . Retrieved 2013/07/31.