2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid

Base Information

• Chemical Name: 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid
• CAS No.: 1610036-10-6
• Molecular Formula: C₂₅H₃₁ClFN₃O₅
• Molecular Weight: 507.99
• Mol file: 1610036-10-6.mol

Synonyms:2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid

Chemical Property of 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid

There total 14 articles about 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 2-((2S,3S,4R)-4-acetoxy-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-3-methylpyrrolidin2-yl)acetate (1610036-14-0) → 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid (1610036-10-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; water; isopropyl alcohol; at 20 ℃; for 5h;

Reference yield:

((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol (1610039-11-6) → 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid (1610036-10-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

1.2: 4 h / 65 °C

2.1: hydrogenchloride / methanol; dichloromethane; acetic acid methyl ester / 21 h / 40 °C

3.1: boron dimethyl-trifluoro sulphide / dichloromethane / 7 h / 0 °C

3.2: 4.33 h / 0 - 20 °C

4.1: dmap; pyridine / dichloromethane / 1.5 h / 20 °C

4.2: 48 h / 20 °C

5.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 36 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran; water; isopropyl alcohol / 5 h / 20 °C

With pyridine; hydrogenchloride; dmap; boron dimethyl-trifluoro sulphide; di-tert-butyl-diazodicarboxylate; water; methanesulfonyl chloride; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetic acid methyl ester; water; isopropyl alcohol;

Reference yield:

2-fluoro-1-iodo-4-methoxybenzene (458-51-5) → 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid (1610036-10-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 24 h / 90 °C / Inert atmosphere

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

2.2: 4 h / 65 °C

3.1: hydrogenchloride / methanol; dichloromethane; acetic acid methyl ester / 21 h / 40 °C

4.1: boron dimethyl-trifluoro sulphide / dichloromethane / 7 h / 0 °C

4.2: 4.33 h / 0 - 20 °C

5.1: dmap; pyridine / dichloromethane / 1.5 h / 20 °C

5.2: 48 h / 20 °C

6.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 36 h / 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran; water; isopropyl alcohol / 5 h / 20 °C

With pyridine; hydrogenchloride; dmap; copper(l) iodide; boron dimethyl-trifluoro sulphide; di-tert-butyl-diazodicarboxylate; water; methanesulfonyl chloride; triethylamine; triphenylphosphine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetic acid methyl ester; water; isopropyl alcohol; butan-1-ol;

upstream raw materials:

2-fluoro-1-iodo-4-methoxybenzene

((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3methylpyrrolidin-2-yl)acetonitrile

methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate