((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

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Chemical Name:((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol
CAS No.:1610039-11-6
Molecular Formula:C₁₄H₂₀FNO₃
Molecular Weight:269.316
Hs Code.:

Synonyms:((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

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Chemical Property of ((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

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Technology Process of ((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

There total 7 articles about ((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1610036-21-9
((2R,3S,4R)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

: 458-51-5
2-fluoro-1-iodo-4-methoxybenzene

: 1610039-11-6
((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

Guidance literature:: With copper(l) iodide; sodium hydroxide; In butan-1-ol; at 90 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1367552-62-2
1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate

: 1610039-11-6
((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 1 h

1.2: 0.75 h / -45 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 24 h / 90 °C / Inert atmosphere

With copper(l) iodide; lithium borohydride; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; mineral oil; butan-1-ol;

Reference yield:

: 1367552-64-4
(2R,3S,4R)-1-benzyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)-3-methylpyrrolidine-1,2-dicarboxylate

: 1610039-11-6
((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 24 h / 90 °C / Inert atmosphere

With copper(l) iodide; lithium borohydride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil; butan-1-ol;