methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate

Base Information

Chemical Name:methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate
CAS No.:1610036-12-8
Molecular Formula:C₁₆H₂₂FNO₄
Molecular Weight:311.353
Hs Code.:

Synonyms:methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate

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Chemical Property of methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate

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Technology Process of methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate

There total 10 articles about methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1610036-11-7
2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3methylpyrrolidin-2-yl)acetonitrile

: 1610036-12-8
methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; acetic acid methyl ester; at 40 ℃; for 21h;

Reference yield:

: 1610039-11-6
((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

: 1610036-12-8
methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

1.2: 4 h / 65 °C

2.1: hydrogenchloride / methanol; dichloromethane; acetic acid methyl ester / 21 h / 40 °C

With hydrogenchloride; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane; acetic acid methyl ester;

Reference yield:

: 458-51-5
2-fluoro-1-iodo-4-methoxybenzene

: 1610036-12-8
methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 24 h / 90 °C / Inert atmosphere

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

2.2: 4 h / 65 °C

3.1: hydrogenchloride / methanol; dichloromethane; acetic acid methyl ester / 21 h / 40 °C

With hydrogenchloride; copper(l) iodide; methanesulfonyl chloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; acetic acid methyl ester; butan-1-ol;