(E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid

Base Information

• Chemical Name: (E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid
• CAS No.: 854737-54-5
• Molecular Formula: C₁₆H₂₄O₄Si
• Molecular Weight: 308.45
• Mol file: 854737-54-5.mol

Synonyms:(E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid

Chemical Property of (E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid

There total 6 articles about (E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)‐tert‐butyldimethylsilyl3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylate (854737-57-8) → (E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid (854737-54-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.5h;

DOI:10.1021/acs.jnatprod.8b00439

Reference yield: 95.0%

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) + tert-butyldimethylsilyl chloride (18162-48-6) → (E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid (854737-54-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 14h;

DOI:10.1002/cmdc.201500246

Reference yield: 95.0%

3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) + tert-butyldimethylsilyl chloride (18162-48-6) → (E)‐3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylic acid (854737-54-5)

Guidance literature:

3-(4-hydroxy-3-methoxyphenyl)acrylic acid; tert-butyldimethylsilyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 24h;

With potassium carbonate; In tetrahydrofuran; water; for 2h;

DOI:10.1016/j.tet.2013.09.068

upstream raw materials:

(E)‐tert‐butyldimethylsilyl3‐(4‐((tert‐butyldimethylsilyl)oxy)‐3‐methoxyphenyl)acrylate

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

tert-butyldimethylsilyl chloride

3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Downstream raw materials:

3-{4-[(tert-butyldimethylsilyl)oxy]-3-methoxyphenyl}propanoic acid