N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide
CAS No.:1201842-02-5
Molecular Formula:C₂₃H₁₉ClFN₅O₃S
Molecular Weight:499.953
Hs Code.:

Synonyms:N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

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Chemical Property of N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

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Technology Process of N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

There total 8 articles about N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 916811-87-5
4-(7-bromoquinoxalin-2-yl)morpholine

: 1112983-31-9
N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

: 1201842-02-5
N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: DOI:10.1021/jm200386s

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 1201842-02-5
N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 100 °C / Inert atmosphere

2: water; sodium carbonate / methanol / 20 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 120 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium acetate; sodium carbonate; In 1,4-dioxane; methanol; 4: Suzuki coupling;
DOI:10.1021/jm200386s

Reference yield:

: 89891-65-6
7-bromo-2-chloroquinoxaline

: 1201842-02-5
N-(2-chloro-5-(3-morpholinoquinoxalin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 1.5 h / 20 °C

2: 60 - 90 °C

With tetrabutyl ammonium fluoride; In dimethyl sulfoxide; 3: Suzuki coupling;
DOI:10.1021/jm200386s