1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone

Base Information

• Chemical Name: 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone
• CAS No.: 470456-00-9
• Molecular Formula: C₁₈H₁₁Cl₂N₃OS
• Molecular Weight: 388.277
• Mol file: 470456-00-9.mol

Synonyms:1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone

Chemical Property of 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone

There total 4 articles about 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

8-Acetyl-9-(4-chloro-phenyl)-7-methyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one (470455-89-1) → 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-00-9)

Guidance literature:

With trichlorophosphate; for 4h; Heating;

DOI:10.1002/jccs.200200035

Reference yield:

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione (103868-29-7) → 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-00-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / CH₃CO₂Na*3H₂O / ethanol / 2 h / Heating

2: 92 percent / NaOEt / ethanol / 0.33 h / Heating

3: 89 percent / Ac₂O / 3 h / Heating

4: 87 percent / POCl₃ / 4 h / Heating

With sodium ethanolate; sodium acetate; acetic anhydride; trichlorophosphate; In ethanol;

DOI:10.1002/jccs.200200035

Reference yield:

2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (470455-87-9) → 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / NaOEt / ethanol / 0.33 h / Heating

2: 89 percent / Ac₂O / 3 h / Heating

3: 87 percent / POCl₃ / 4 h / Heating

With sodium ethanolate; acetic anhydride; trichlorophosphate; In ethanol;

DOI:10.1002/jccs.200200035

upstream raw materials:

8-Acetyl-9-(4-chloro-phenyl)-7-methyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione

2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide

5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide

Downstream raw materials:

1-[9-(4-Chloro-phenyl)-4-hydrazino-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone