2-{[5-acetyl-4-(4-chlorophenyl)-3-cyano-6-methyl-2-pyridinyl]sulfanyl}acetamide

Base Information

• Chemical Name: 2-{[5-acetyl-4-(4-chlorophenyl)-3-cyano-6-methyl-2-pyridinyl]sulfanyl}acetamide
• CAS No.: 470455-87-9
• Molecular Formula: C₁₇H₁₄ClN₃O₂S
• Molecular Weight: 359.836
• Mol file: 470455-87-9.mol

Synonyms:2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide

Chemical Property of 2-{[5-acetyl-4-(4-chlorophenyl)-3-cyano-6-methyl-2-pyridinyl]sulfanyl}acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[5-acetyl-4-(4-chlorophenyl)-3-cyano-6-methyl-2-pyridinyl]sulfanyl}acetamide

There total 1 articles about 2-{[5-acetyl-4-(4-chlorophenyl)-3-cyano-6-methyl-2-pyridinyl]sulfanyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione (103868-29-7) + Chloroacetamide (79-07-2) → 2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (470455-87-9)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Heating;

DOI:10.1002/jccs.200200035

Reference yield: 92.0%

2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (470455-87-9) → 5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide (380638-22-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.333333h; Heating;

DOI:10.1002/jccs.200200035

Reference yield:

2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (470455-87-9) → 1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / NaOEt / ethanol / 0.33 h / Heating

2: 89 percent / Ac₂O / 3 h / Heating

3: 87 percent / POCl₃ / 4 h / Heating

With sodium ethanolate; acetic anhydride; trichlorophosphate; In ethanol;

DOI:10.1002/jccs.200200035

upstream raw materials:

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione

Chloroacetamide

Downstream raw materials:

5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide

1-[4-Chloro-9-(4-chloro-phenyl)-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone

8-Acetyl-9-(4-chloro-phenyl)-7-methyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one

1-[4-Chloro-9-(4-chloro-phenyl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone