(S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate

Base Information

Chemical Name:(S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate
CAS No.:1398547-76-6
Molecular Formula:C₁₆H₂₁F₂NO₅
Molecular Weight:345.343
Hs Code.:

Synonyms:(S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate

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Chemical Property of (S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate

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Technology Process of (S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate

There total 3 articles about (S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1-((1S)-2-bromo-1-(methoxymethoxy)-2-nitroethyl)-3,5-difluorobenzene

: 39613-92-8,62062-56-0,62062-65-1
alanine isopropyl ester hydrochloride

: 1398547-76-6
(S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate

Guidance literature:: With N-iodo-succinimide; oxygen; potassium carbonate; In 2-methyltetrahydrofuran; water; at 0 ℃; for 36h;
DOI:10.1021/ja306225u

Reference yield:

: 32085-88-4
3,5-difluorobenzaldehyde

: 1398547-76-6
(S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; Cu(2-IC₆H₄COO)2*H₂O / isopropyl alcohol / 0.17 h / -20 °C

1.2: 118 h

2.1: phosphorus pentoxide / chloroform / 20 °C

3.1: potassium carbonate; N-iodo-succinimide; oxygen / water; 2-methyltetrahydrofuran / 36 h / 0 °C

With N-iodo-succinimide; Cu(2-IC₆H₄COO)2*H₂O; phosphorus pentoxide; oxygen; potassium carbonate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; In 2-methyltetrahydrofuran; chloroform; water; isopropyl alcohol; 1.1: |Henry Nitro Aldol Condensation / 1.2: |Henry Nitro Aldol Condensation;
DOI:10.1021/ja306225u

Reference yield:

: 1398547-93-7
C₈H₆BrF₂NO₃

: 1398547-76-6
(S)-isopropyl 2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentoxide / chloroform / 20 °C

2: potassium carbonate; N-iodo-succinimide; oxygen / water; 2-methyltetrahydrofuran / 36 h / 0 °C

With N-iodo-succinimide; phosphorus pentoxide; oxygen; potassium carbonate; In 2-methyltetrahydrofuran; chloroform; water;
DOI:10.1021/ja306225u