6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

Base Information

Chemical Name:6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester
CAS No.:383875-96-5
Molecular Formula:C₂₃H₂₁F₂NO₃
Molecular Weight:397.421
Hs Code.:

Synonyms:6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

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Chemical Property of 6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

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Technology Process of 6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

There total 4 articles about 6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 870-63-3
prenyl bromide

: 346687-19-2
6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

: 383875-96-5
6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 6h;

Reference yield:

: 20372-63-8
4,5-difluoro-2-nitrobenzoic acid

: 383875-96-5
6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: SOCl₂; urea / toluene / 3 h / 100 °C

2.1: Mg; EtOH / CCl₄; toluene / 2 h

2.2: toluene; CCl₄ / 0.5 h / 20 °C

3.1: 71 percent / H₂ / 10 percent Pd/C / ethanol / 3 h / 20 °C

4.1: 72 percent / K₂CO₃ / dimethylformamide / 6 h / 80 - 90 °C

With thionyl chloride; ethanol; hydrogen; potassium carbonate; magnesium; urea; palladium on activated charcoal; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 129951-46-8
4,5-difluoro-2-nitrobenzoyl chloride

: 383875-96-5
6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg; EtOH / CCl₄; toluene / 2 h

1.2: toluene; CCl₄ / 0.5 h / 20 °C

2.1: 71 percent / H₂ / 10 percent Pd/C / ethanol / 3 h / 20 °C

3.1: 72 percent / K₂CO₃ / dimethylformamide / 6 h / 80 - 90 °C

With ethanol; hydrogen; potassium carbonate; magnesium; palladium on activated charcoal; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; toluene;