N²-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N¹,N²-bis[2-(tritylthio)ethyl]glycinamide

Base Information

• Chemical Name: N²-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N¹,N²-bis[2-(tritylthio)ethyl]glycinamide
• CAS No.: 848087-36-5
• Molecular Formula: C₅₁H₅₇N₃O₈P₂S₂
• Molecular Weight: 966.108
• Mol file: 848087-36-5.mol

Synonyms:N²-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N¹,N²-bis[2-(tritylthio)ethyl]glycinamide

Chemical Property of N²-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N¹,N²-bis[2-(tritylthio)ethyl]glycinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N¹,N²-bis[2-(tritylthio)ethyl]glycinamide

There total 4 articles about N²-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N¹,N²-bis[2-(tritylthio)ethyl]glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.1%

[1-phosphono-3-[4-[[2-(tritylthio)ethyl][[2-(tritylthio)ethylcarbamoyl]methyl]amino]butyrylamino]propyl]phosphonic acid tetraethyl ester (848087-35-4) → N2-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N1,N2-bis[2-(tritylthio)ethyl]glycinamide (848087-36-5)

Guidance literature:

With trimethylsilyl bromide; In chloroform; at 20 - 50 ℃; for 39h;

DOI:10.1002/jlcr.864

Reference yield:

N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide (152863-83-7) → N2-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N1,N2-bis[2-(tritylthio)ethyl]glycinamide (848087-36-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 52.9 percent / ethyldiisopropylamine / dimethylformamide / 3 h / 90 °C

2: 98 percent / NaOH

3: 65.3 percent / DCC / CHCl₃ / 5 h / 20 °C

4: 39.1 percent / trimethylsilylbromide / CHCl₃ / 39 h / 20 - 50 °C

With sodium hydroxide; trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In chloroform; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.864

Reference yield:

N-[2-(tritylthio)ethylaminocarbonylmethyl]-N-[2-(tritylthio)ethyl]-4-aminobutyric acid (228253-41-6) → N2-[4-[(3,3-diphosphonopropyl)amino]-4-oxobutyl]-N1,N2-bis[2-(tritylthio)ethyl]glycinamide (848087-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 65.3 percent / DCC / CHCl₃ / 5 h / 20 °C

2: 39.1 percent / trimethylsilylbromide / CHCl₃ / 39 h / 20 - 50 °C

With trimethylsilyl bromide; dicyclohexyl-carbodiimide; In chloroform;

DOI:10.1002/jlcr.864

upstream raw materials:

[1-phosphono-3-[4-[[2-(tritylthio)ethyl][[2-(tritylthio)ethylcarbamoyl]methyl]amino]butyrylamino]propyl]phosphonic acid tetraethyl ester

N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide

N-[2-(tritylthio)ethylaminocarbonylmethyl]-N-[2-(tritylthio)ethyl]-4-aminobutyric acid

4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid ethyl ester