N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide
• CAS No.: 87023-89-0
• Molecular Formula: C₁₅H₁₉N₃O₃S
• Molecular Weight: 321.4
• Mol file: 87023-89-0.mol

Synonyms:N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide

Chemical Property of N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide

There total 4 articles about N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-(p-toluenesulfonyl)-DL-alanine (21957-58-4,85471-45-0,4816-81-3) + O-ethylphosphoric acid bis(3,5-dimethyl)pyrazolide (87023-83-4) → N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide (87023-89-0)

Guidance literature:

In pyridine; Ambient temperature;

Reference yield: 76.0%

1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one (37612-61-6) + [N-(p-tolylsulfonyl)imino]phenyliodinane (55962-05-5) → N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide (87023-89-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 0 ℃; for 48h; Reagent/catalyst; chemoselective reaction; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1021/jacs.5b11773

Reference yield:

3,5-dimethyl-1H-pyrazole (67-51-6) → N-(1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide (87023-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: 79 percent / pyridine / Ambient temperature

In pyridine; benzene;

upstream raw materials:

N-(p-toluenesulfonyl)-DL-alanine

O-ethylphosphoric acid bis(3,5-dimethyl)pyrazolide

3,5-dimethyl-1H-pyrazole

1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one

Downstream raw materials:

ethyl N-tosylalaninate

4-methyl-N-(1-oxo-1-phenylpropan-2-yl)benzene sulfonamide

N-(p-toluenesulfonyl)-DL-alanine

(+/-)-N₁-(1-methyl-2-oxoethyl)-4-methyl-1-benzenesulfonamide