Technology Process of methyl 4-chloro-6-(4-(4-fluorophenoxy)phenyl)picolinate
There total 6 articles about methyl 4-chloro-6-(4-(4-fluorophenoxy)phenyl)picolinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
In
tetrahydrofuran;
at 60 ℃;
for 14h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C
3.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C
3.2: 0.5 h / 0 °C
4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Inert atmosphere; Reflux
With
sulfuric acid; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; sodium nitrite;
bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 5%-palladium/activated carbon;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C
1.2: 0.5 h / 0 °C
2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Inert atmosphere; Reflux
With
sulfuric acid; potassium acetate; sodium carbonate; sodium nitrite;
bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; 1,2-dimethoxyethane; water;