Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

Base Information

Chemical Name:Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide
CAS No.:1310475-79-6
Molecular Formula:C₂₅H₃₃FN₂O₅S
Molecular Weight:492.612
Hs Code.:

Synonyms:Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

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Chemical Property of Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

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Technology Process of Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

There total 4 articles about Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 75-30-9
2-iodo-propane

: 1310473-43-8
trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

: 1310475-79-6
Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

Guidance literature:: With potassium carbonate; tetra-(n-butyl)ammonium iodide; In water; N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 914261-11-3
4-Hydroxy-3-methoxy-benzenesulphonyl chloride

: 1310475-79-6
Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; water / 15 h / 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; tetra-(n-butyl)ammonium iodide; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1310478-73-9
(1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride

: 1310475-79-6
Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; water / 15 h / 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; tetra-(n-butyl)ammonium iodide; In dichloromethane; water; N,N-dimethyl-formamide;