(1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

Base Information

Chemical Name:(1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid
CAS No.:1204417-50-4
Molecular Formula:C₃₃H₄₂N₄O₇S
Molecular Weight:638.785
Hs Code.:

(1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

Synonyms:(1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

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Chemical Property of (1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

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Technology Process of (1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

There total 16 articles about (1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1204417-52-6
tert-butyl (1aS,12bR)-8-cyclohexyl-11-methoxy-1a-(methyl{2-[2-(methylamino)ethoxy]ethyl}carbamoyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

: 1204417-50-4
(1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

Guidance literature:: With SULFAMIDE; In 1,4-dioxane; at 100 ℃; for 3h; Microwave irradiation;

Reference yield: 26.0%

: 1204417-49-1
(1aR,12bS)-8-cyclohexyl-11-methoxy-1a-(methyl{2-[2-(methylamino)ethoxy]ethyl}carbamoyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

: 1204417-50-4
(1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

Guidance literature:: With SULFAMIDE; In 1,4-dioxane; at 100 ℃; for 4h; Microwave irradiation;

Reference yield:

: 928844-30-8
13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

: 1204417-50-4
(1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / dimethyl sulfoxide / 20 °C

1.2: 50 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0 °C

4.1: n-butyllithium / tetrahydrofuran / -78 °C

4.2: -78 °C

5.1: methanol; sodium hydroxide / tetrahydrofuran / 20 °C

6.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran

7.1: sulfonamide / 1,2-dioxacyclohexane / 100 °C

8.1: trifluoroacetic acid / dichloromethane

With methanol; sulfonamide; n-butyllithium; oxalyl dichloride; water; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,2-dioxacyclohexane; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.04.113