(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

Base Information

Chemical Name:(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal
CAS No.:126706-14-7
Molecular Formula:C₂₂H₁₇F₃N₂O
Molecular Weight:382.385
Hs Code.:

Synonyms:(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

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Chemical Property of (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

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Technology Process of (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

There total 5 articles about (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 126706-17-0
(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol

: 126706-14-7
(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

Guidance literature:: With pyridine; chromium(VI) oxide; In dichloromethane; at 23 ℃; for 2h;
DOI:10.1016/S0040-4039(01)93462-8

Reference yield:

: 126706-09-0,126706-13-6
(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-acrylonitrile

: 126706-10-3
(E)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

: 126706-14-7
(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -10 ℃; for 2h; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(01)93462-8

Reference yield:

: 122253-18-3
[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol

: 126706-14-7
(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-propenal

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / CrO₃, pyridine / CH₂Cl₂ / 0 °C

2: 72 percent / NaH / 1,2-dimethoxy-ethane / 2 h / 20 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -10 °C

With pyridine; chromium(VI) oxide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/S0040-4039(01)93462-8