S-ethyl 2-phenylpropionic acid thioester

Base Information

• Chemical Name: S-ethyl 2-phenylpropionic acid thioester
• CAS No.: 169139-76-8
• Molecular Formula: C₁₁H₁₄OS
• Molecular Weight: 194.298
• Mol file: 169139-76-8.mol

Synonyms:S-ethyl 2-phenylpropionic acid thioester

Chemical Property of S-ethyl 2-phenylpropionic acid thioester

Chemical Property:

Purity/Quality:

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Technology Process of S-ethyl 2-phenylpropionic acid thioester

There total 7 articles about S-ethyl 2-phenylpropionic acid thioester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

hydratropic acid (492-37-5,2328-24-7) + ethanethiol (75-08-1) → S-ethyl 2-phenylpropionic acid thioester (169139-76-8)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1002/chem.201801887

Reference yield: 96.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide (50978-45-5) + ethanethiol (75-08-1) → S-ethyl 2-phenylpropionic acid thioester (169139-76-8)

Guidance literature:

3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide; With sodium carbonate; N,N-dimethyl-formamide;

styrene; ethanethiol; With diphenyl hydrogen phosphate; 1-(diphenylphosphino)ferrocene-1-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 14h; regioselective reaction;

DOI:10.1021/jacs.6b11020

Reference yield: 82.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + carbon monoxide (201230-82-2) + ethanethiol (75-08-1) → S-ethyl 3-phenylpropionic acid thioester (30911-16-1) + S-ethyl 2-phenylpropionic acid thioester (169139-76-8)

Guidance literature:

With 5-chloro-2-hydroxybenzoic acid; boric acid; bis[2-(diphenylphosphino)phenyl] ether; palladium dichloride; In acetonitrile; at 120 ℃; under 15001.5 Torr;

DOI:10.1021/acscatal.1c00414

upstream raw materials:

(E)-(1-phenylethyl)(ethylthio)sulfine

2-phenylpropionyl chloride

ethanethiol

hydratropic acid

Downstream raw materials:

1,1'-ethylidenebis-benzene

1,2-diphenylpropan-1-one