31756-14-6

Basic information

• Product Name: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline
• Synonyms: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline;2-Benzyl-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline;N-benzyl-6,7-diMethoxy-1,2,3,4-tetrahydroisoquinoline;2-Benzyl-6,7-diMethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 31756-14-6
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.36484
• Mol File: 31756-14-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 85-87℃
• Appearance: /
• Density: 1.117
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline(31756-14-6)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline(31756-14-6)

Safety Data

• Hazardous Substances Data: 31756-14-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 43, p. 159, 1995 DOI: 10.1248/cpb.43.159

Upstream product

• 50-00-0 formaldehyd 
• 51973-93-4 N-benzyl-2-(3,4-dimethoxyphenyl)ethylamine 
• 5096-82-2 benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium hydrobromide 
• 1472-54-4 N-benzyl-3,4-dimethoxyphenethylamine hydrochloride 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 1201681-89-1 3-benzyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 2328-12-3 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride 
• 100-39-0 benzyl bromide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 10133-74-1 N-phenylmethylene-2-(3,4-dimethoxyphenyl)ethylamine 
• 113967-02-5 Benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-ethoxymethyl-amine 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 900784-81-8 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide 
• 900784-48-7 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol 
• 65745-73-5 2-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

A convenient synthesis of tertiary amines by alkylation of secondary amines with alkyl halides in the presence of potassium hydride and triethylamine

N-Alkylation of secondary amines with alkyl halides in the presence of potassium hydride and triethylamine gave corresponding tertiary amines in satisfactory yields.

Visible-Light-Mediated C(sp3)–H Thiocarbonylation for Thiolactam Preparation with Potassium Sulfide

We report herein a protocol for thiolactam preparation with potassium sulfide via visible-light-mediated C(sp3)–H thiocarbonylation, in which polysulfide dianions and radical anions generated from potassium sulfide were the key active species. A variety of thiolactams were straightforward established under mild conditions. Moreover, it was successfully applied to structural modification of tetrahydroberberine.

Modified B-alkylcatecholboranes as radical precursors

Generation of radicals from B-alkylcatecholboranes represents an efficient tin-free procedure for the generation of alkyl radicals. A modified version of this method has been developed. The simple catechol is replaced by a dihydroxylated tetrahydroisoquin