(2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid

Base Information

Chemical Name:(2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid
CAS No.:197777-87-0
Molecular Formula:C₂₁H₂₄ClNO₆
Molecular Weight:421.878
Hs Code.:

Synonyms:(2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid

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Technology Process of (2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid

There total 12 articles about (2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 197778-03-3
(2R,3R)-3-Acetoxy-3-(4-benzyloxy-3-chloro-phenyl)-2-tert-butoxycarbonylamino-propionic acid

: 197777-87-0
(2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid

Guidance literature:: With potassium carbonate; In methanol; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4039(97)01749-8

Reference yield:

: 197778-02-2
(2S,3R)-3-acetoxy-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylaminopropan-1-ol

: 197777-87-0
(2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / Jones reagent / acetone / 1 h / 0 °C

2: 94 percent / K₂CO₃ / methanol / 0.5 h / Ambient temperature

With jones reagent; potassium carbonate; In methanol; acetone;
DOI:10.1016/S0040-4039(97)01749-8

Reference yield:

: 197777-86-9
(2S,3R)-3-acetoxy-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-1,2-cyclohexylidenepropan-1-ol

: 197777-87-0
(2R,3R)-3-(4-benzyloxy-3-chlorophenyl)-2-tert-butoxycarbonylamino-3-hydroxypropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / TFA / H₂O; CH₂Cl₂ / 1 h / Ambient temperature

2: 54 percent / Jones reagent / acetone / 1 h / 0 °C

3: 94 percent / K₂CO₃ / methanol / 0.5 h / Ambient temperature

With jones reagent; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(97)01749-8