(E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

Base Information

• Chemical Name: (E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide
• CAS No.: 1422427-60-8
• Molecular Formula: C₁₁H₉BrN₄S
• Molecular Weight: 309.189
• Mol file: 1422427-60-8.mol

Synonyms:(E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

Chemical Property of (E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

There total 1 articles about (E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chloropyridine-3-carbonitrile (405224-23-9) → (E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide (1422427-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / water; N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 2 h / 0 °C

2.1: 0.5 h / 90 °C / Microwave irradiation

With potassium hydroxide; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2012.12.077

Reference yield: 99.0%

(E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide (1422427-60-8) + (2-fluoro-4-methoxyphenyl)boronic acid (162101-31-7) → (E)-N'-(5-(2-fluoro-4-methoxyphenyl)-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 1.5h; under 760.051 Torr; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.12.038

Reference yield: 99.0%

(E)-N′-(5-bromo-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide (1422427-60-8) + phenylboronic acid (98-80-6) → (E)-N'-(2-cyano-5-phenylthieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide (1422427-61-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 1.5h; Microwave irradiation;

DOI:10.1016/j.tetlet.2012.12.077

upstream raw materials:

5-bromo-2-chloropyridine-3-carbonitrile

Downstream raw materials:

(E)-N'-(2-cyano-5-phenylthieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

(E)-N'-(2-cyano-5-(p-tolyl)thieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

(E)-N'-(2-cyano-5-(4-methoxyphenyl)thieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide

(E)-N'-(5-(4-chlorophenyl)-2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide