ethyl 3-(o-hydroxyphenyl)propoxyacetate

Base Information

• Chemical Name: ethyl 3-(o-hydroxyphenyl)propoxyacetate
• CAS No.: 77420-29-2
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.284
• Mol file: 77420-29-2.mol

Synonyms:ethyl 3-(o-hydroxyphenyl)propoxyacetate

Chemical Property of ethyl 3-(o-hydroxyphenyl)propoxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(o-hydroxyphenyl)propoxyacetate

There total 9 articles about ethyl 3-(o-hydroxyphenyl)propoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(2-hydroxyphenyl)propanoate (20921-04-4) → ethyl 3-(o-hydroxyphenyl)propoxyacetate (77420-29-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / conc. hydrochloric acid / 2.75 h / 40 °C

2: 83 percent / LiAlH₄ / diethyl ether / 0.75 h / Heating

3: 1.) NaH, 2.) toluene-p-sulphonic acid / 1.) DMF, steam-bath, 1 h, 2.) reflux, 24 h

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; toluene-4-sulfonic acid; In diethyl ether;

DOI:10.1039/P19810000336

Reference yield:

2-methoxy-benzenepropanoic acid (6342-77-4) → ethyl 3-(o-hydroxyphenyl)propoxyacetate (77420-29-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 59 percent / pyridinium chloride / H₂O / 0.33 h / Heating

2: 76 percent / sodium ethoxide / 1 h / 40 °C

3: 75 percent / conc. hydrochloric acid / 2.75 h / 40 °C

4: 83 percent / LiAlH₄ / diethyl ether / 0.75 h / Heating

5: 1.) NaH, 2.) toluene-p-sulphonic acid / 1.) DMF, steam-bath, 1 h, 2.) reflux, 24 h

With hydrogenchloride; lithium aluminium tetrahydride; sodium ethanolate; pyridine hydrochloride; sodium hydride; toluene-4-sulfonic acid; In diethyl ether; water;

DOI:10.1039/P19810000336

Reference yield:

3-(2'-methoxyphenyl)propenoic acid (6099-03-2) → ethyl 3-(o-hydroxyphenyl)propoxyacetate (77420-29-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 94 percent / Ni-Al alloy, alkaline solution / 90 °C

2: 59 percent / pyridinium chloride / H₂O / 0.33 h / Heating

3: 76 percent / sodium ethoxide / 1 h / 40 °C

4: 75 percent / conc. hydrochloric acid / 2.75 h / 40 °C

5: 83 percent / LiAlH₄ / diethyl ether / 0.75 h / Heating

6: 1.) NaH, 2.) toluene-p-sulphonic acid / 1.) DMF, steam-bath, 1 h, 2.) reflux, 24 h

With hydrogenchloride; lithium aluminium tetrahydride; aluminum nickel; alkaline solution; sodium ethanolate; pyridine hydrochloride; sodium hydride; toluene-4-sulfonic acid; In diethyl ether; water;

DOI:10.1039/P19810000336

upstream raw materials:

ethanol

sodium 2-bromoacetate

3-[2-(tetrahydropyran-2-yloxy)phenyl]propan-1-ol

2-methoxy-benzenepropanoic acid

Downstream raw materials:

methyl 4-(o-ethoxycarbonylmethoxypropylphenoxy)butyrate