diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

Base Information

Chemical Name:diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate
CAS No.:220545-74-4
Molecular Formula:C₃₀H₃₈N₆O₈
Molecular Weight:610.667
Hs Code.:

Synonyms:diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

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Chemical Property of diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

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Technology Process of diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

There total 8 articles about diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 220545-92-6
diethyl 4-<(10-methoxy-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

: 220545-74-4
diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

Guidance literature:: With trimethylsilyl iodide; In dichloromethane; for 1.5h; Heating;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 220545-79-9
2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine

: 220545-74-4
diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / methanol / 3.5 h / Heating

2: 83 percent / DMAP / toluene / 48 h / Heating

3: 94 percent / H₂ / Pd/BaSO₄ / pyridine / 5 h / 760 Torr / Ambient temperature

4: 65 percent / palladium acetate, PPh₃, CuI, Et₃N / acetonitrile / 96 h / 55 °C

5: 99 percent / NH₂OH*HCl, pyridine / ethanol / 3 h / Ambient temperature

6: 1.) NCS, 2.) Et₃N / 1.) CH₂Cl₂, room temperature, 3 h, 2.) 3 h

7: 90 percent / TFA / 72 h / 45 °C

8: 82 percent / TMSI / CH₂Cl₂ / 1.5 h / Heating

With pyridine; dmap; N-chloro-succinimide; copper(l) iodide; trimethylsilyl iodide; hydroxylamine hydrochloride; hydrogen; palladium diacetate; triethylamine; triphenylphosphine; trifluoroacetic acid; Pd-BaSO₄; In pyridine; methanol; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 220545-81-3
2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

: 220545-74-4
diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / DMAP / toluene / 48 h / Heating

2: 94 percent / H₂ / Pd/BaSO₄ / pyridine / 5 h / 760 Torr / Ambient temperature

3: 65 percent / palladium acetate, PPh₃, CuI, Et₃N / acetonitrile / 96 h / 55 °C

4: 99 percent / NH₂OH*HCl, pyridine / ethanol / 3 h / Ambient temperature

5: 1.) NCS, 2.) Et₃N / 1.) CH₂Cl₂, room temperature, 3 h, 2.) 3 h

6: 90 percent / TFA / 72 h / 45 °C

7: 82 percent / TMSI / CH₂Cl₂ / 1.5 h / Heating

With pyridine; dmap; N-chloro-succinimide; copper(l) iodide; trimethylsilyl iodide; hydroxylamine hydrochloride; hydrogen; palladium diacetate; triethylamine; triphenylphosphine; trifluoroacetic acid; Pd-BaSO₄; In pyridine; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4020(98)01060-6