2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine

Base Information

• Chemical Name: 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine
• CAS No.: 220545-79-9
• Molecular Formula: C₁₇H₁₇ClN₄O₂
• Molecular Weight: 344.801
• Mol file: 220545-79-9.mol

Synonyms:2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine

Chemical Property of 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine

There total 2 articles about 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-amino-4,6-dichloropyrimidine-5-carboxaldehyde (5604-46-6) + N-(4-methoxybenzyl)-4-amino-1-butyne (146980-79-2) → 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine (220545-79-9)

Guidance literature:

With triethylamine; In ethanol; for 6h; Heating;

DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine (220545-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N, 3.) NaBH₄ / 1.) MeOH, room temperature, 1 h, 2.) room temperature, 1 h, 3.) 0 deg C, 1 h

2: 98 percent / Et₃N / ethanol / 6 h / Heating

With sodium tetrahydroborate; triethylamine; In ethanol;

DOI:10.1016/S0040-4020(98)01060-6

Reference yield: 80.0%

sodium methylate (124-41-4) + 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine (220545-79-9) → 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine (220545-81-3)

Guidance literature:

In methanol; for 3.5h; Heating;

DOI:10.1016/S0040-4020(98)01060-6

upstream raw materials:

2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

N-(4-methoxybenzyl)-4-amino-1-butyne

4-methoxy-benzaldehyde

Downstream raw materials:

2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

diethyl 4-<(10(9H)-oxo-8-pivaloylamino)-3,4,5,6-tetrahydro-(6H)-isoxazolino<3,4-d>pyrimido<4,5-b>azepin-3-yl>benzoyl-L-glutamate