17,21-Dihydroxy-pregn-5-ene-3,11,20-trione 3,20-Diethylene Ketal

Base Information

• Chemical Name: 17,21-Dihydroxy-pregn-5-ene-3,11,20-trione 3,20-Diethylene Ketal
• CAS No.: 101524-47-4
• Molecular Formula: C₂₅H₃₆O₇
• Molecular Weight: 448.557
• Mol file: 101524-47-4.mol

Synonyms:3,3;20,20-bis-ethanediyldioxy-17,21-dihydroxy-pregn-5-en-11-one

Chemical Property of 17,21-Dihydroxy-pregn-5-ene-3,11,20-trione 3,20-Diethylene Ketal

Chemical Property:

• Melting Point: 234-238.5 °C
• Boiling Point: 615.3±55.0 °C(Predicted)
• PKA: 14.41±0.60(Predicted)
• Density: 1.32±0.1 g/cm3(Predicted)
• Solubility.: Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

17,21-Dihydroxy-pregn-5-ene-3,11,20-trione3,20-DiethyleneKetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Cortisol derivatives.

Technology Process of 17,21-Dihydroxy-pregn-5-ene-3,11,20-trione 3,20-Diethylene Ketal

There total 5 articles about 17,21-Dihydroxy-pregn-5-ene-3,11,20-trione 3,20-Diethylene Ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,20-bis(ethylenedioxy)-11α,17α,21-trihydroxypregn-5-ene (102030-55-7) → 3,3;20,20-bis-ethanediyldioxy-17,21-dihydroxy-pregn-5-en-11-one (101524-47-4)

Guidance literature:

With pyridine; chromium(VI) oxide;

DOI:10.1021/ja01652a075

Reference yield:

Epicortisol (566-35-8) → 3,3;20,20-bis-ethanediyldioxy-17,21-dihydroxy-pregn-5-en-11-one (101524-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene; toluene-4-sulfonic acid

2: chromium (VI)-oxide; pyridine

With pyridine; chromium(VI) oxide; toluene-4-sulfonic acid; benzene;

DOI:10.1021/ja01652a075

Reference yield:

17,21-dihydroxy-pregn-4-ene-3,11,20-trione (53-06-5,10007-36-0,15779-07-4,35446-72-1,104713-00-0) + ethylene glycol (107-21-1) → 3,3;20,20-bis-ethanediyldioxy-17,21-dihydroxy-pregn-5-en-11-one (101524-47-4)

Guidance literature:

With toluene-4-sulfonic acid; benzene;

DOI:10.1021/jo01129a013

upstream raw materials:

17,21-dihydroxy-pregn-4-ene-3,11,20-trione

ethylene glycol

3,20-bis(ethylenedioxy)-11α,17α,21-trihydroxypregn-5-ene

Epicortisol

Downstream raw materials:

HYDROCORTISONE

3,20-bis(ethylenedioxy)-11α,17α,21-trihydroxypregn-5-ene

3,3;20,20-bis-ethanediyldioxy-pregn-5-ene-11β,17,21-triol

3,3;20,20-bis-ethanediyldioxy-17-hydroxy-21-(toluene-4-sulfonyloxy)-pregn-5-en-11-one