Technology Process of methyl (2S,3R)-2-(methanesulfonyloxy)-3-phenylbutanoate
There total 17 articles about methyl (2S,3R)-2-(methanesulfonyloxy)-3-phenylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 5h;
DOI:10.1021/jo971178f
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium bicarbonate; sodium periodate / ruthenium trichloride trihydrate / CCl4; acetonitrile; H2O / 48 h
2.1: CuCN / diethyl ether; hexane / 0 °C
2.2: diethyl ether; hexane / 4 h / 0 °C
3.1: 0.18 g / KHCO3 / dimethylformamide / 12 h / 20 °C
4.1: 93 percent / PPh3; diethyl azodicarboxylate / benzene / 12 h / 20 °C
5.1: 0.29 g / aq. LiOH / tetrahydrofuran / 0.58 h / 70 °C
6.1: 80 percent / KHCO3 / dimethylformamide / 5 h / 20 °C
7.1: 91 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / 0 - 20 °C
With
dmap; lithium hydroxide; sodium periodate; sodium hydrogencarbonate; potassium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
ruthenium trichloride;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
1.1: Oxidation / 2.1: transmetallation / 2.2: Ring cleavage / 3.1: Esterification / 4.1: Mitsunobu reaction / 5.1: Hydrolysis / 6.1: Esterification / 7.1: mesylation;
DOI:10.1021/jo971178f
- Guidance literature:
-
With
potassium hydrogencarbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
DOI:10.1021/jo971178f
