ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate

Base Information

Chemical Name:ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate
CAS No.:1312771-23-5
Molecular Formula:C₂₄H₃₁ClN₂O₇
Molecular Weight:494.972
Hs Code.:

Synonyms:ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate

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Chemical Property of ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate

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Technology Process of ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate

There total 3 articles about ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-60-7
(2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 1312771-23-5
ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1.5 h / 35 °C

3.1: methanesulfonic acid / ethanol / 6 h / 40 °C

3.2: Cooling with ice

4.1: triethylamine; sodium tris(acetoxy)borohydride / ethanol / 3.5 h / 20 °C / Cooling with ice

4.2: Cooling with ice

With methanesulfonic acid; boron tribromide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;

Reference yield:

: 1312771-22-4
ethyl (2R)-2-{3-[(tert-butoxycarbonyl)amino]-2-[5-chloro-2-(tert-butoxycarbonyl)oxybenzyl]propanamide}acetate

: 1312771-23-5
ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonic acid / ethanol / 6 h / 40 °C

1.2: Cooling with ice

2.1: triethylamine; sodium tris(acetoxy)borohydride / ethanol / 3.5 h / 20 °C / Cooling with ice

2.2: Cooling with ice

With methanesulfonic acid; sodium tris(acetoxy)borohydride; triethylamine; In ethanol;

Reference yield:

: 1312771-21-3
(2R)-3-[(tert-butoxycarbonyl)amino]-2-[2-(tert-butoxycarbonyl)oxy-5-chlorobenzyl]propanoic acid

: 1312771-23-5
ethyl (2R)-2-{(5-chloro-hydroxybenzyl)-3-[(2,4,6-trimethoxybenzyl)amino]propanamide}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1.5 h / 35 °C

2.1: methanesulfonic acid / ethanol / 6 h / 40 °C

2.2: Cooling with ice

3.1: triethylamine; sodium tris(acetoxy)borohydride / ethanol / 3.5 h / 20 °C / Cooling with ice

3.2: Cooling with ice

With methanesulfonic acid; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;