Technology Process of ethyl 3-benzylsulfonylindol-1-ylacetate
There total 4 articles about ethyl 3-benzylsulfonylindol-1-ylacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(benzylsulfonyl)-1H-indole;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.166667h;
ethyl bromoacetate;
In
N,N-dimethyl-formamide; mineral oil;
for 5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium iodide; thiourea; iodine / water; methanol / 2 h / 20 °C
1.2: 0.5 h / 85 °C
1.3: 20 °C
2.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h
2.2: 0.17 h / 20 °C
3.1: sodium hydrogencarbonate; Oxone / water; acetone / 18 h
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h
4.2: 5 h
With
Oxone; iodine; sodium hydride; sodium hydrogencarbonate; thiourea; potassium iodide;
In
1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetone; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate; Oxone / water; acetone / 18 h
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h
2.2: 5 h
With
Oxone; sodium hydride; sodium hydrogencarbonate;
In
water; N,N-dimethyl-formamide; acetone; mineral oil;
