(-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran

Base Information

Chemical Name:(-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran
CAS No.:138432-66-3
Molecular Formula:C₁₇H₂₈O₃Si₂
Molecular Weight:336.579
Hs Code.:

Synonyms:(-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran

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Chemical Property of (-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran

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Technology Process of (-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran

There total 5 articles about (-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 138512-16-0
(-)-(2R,3R,4R)-3,4-dihydroxy-2-phenyl-2,3-dihydro-4H-pyran

: 18156-74-6
1-(Trimethylsilyl)imidazole

: 138432-66-3
(-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran

Guidance literature:: In dichloromethane; for 1h;

Reference yield:

: 100-52-7
benzaldehyde

: 138432-66-3
(-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) BF₃*Et₂O, 2.) trifluoroacetic acid / 1.) CH₂Cl₂, from -78 deg C to -40 deg C, 2 h, 2.) CCl₄, RT

2: 97 percent / CeCl₃*7H₂O, NaBH₄ / CH₂Cl₂; ethanol / 0.33 h / -78 °C

3: 1,2-dimethoxy-ethane / 168 h / lipase PS-30

4: 94 percent / K₂CO₃ / methanol / 3 h / Ambient temperature

5: 84 percent / CH₂Cl₂ / 1 h

With sodium tetrahydroborate; cerium(III) chloride; boron trifluoride diethyl etherate; potassium carbonate; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 138512-01-3
(2R*,3R*,4R*)-3-(benzoyloxy)-4-hydroxy-2-phenyl-2,3-dihydro-4H-pyran

: 138432-66-3
(-)-(2R,3S,4R)-2-phenyl-3,4-bis<(trimethylsilyl)oxy>-2,3-dihydro-4H-pyran

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dimethoxy-ethane / 168 h / lipase PS-30

2: 94 percent / K₂CO₃ / methanol / 3 h / Ambient temperature

3: 84 percent / CH₂Cl₂ / 1 h

With potassium carbonate; In methanol; 1,2-dimethoxyethane; dichloromethane;