ETHYL O-CARBOETHOXYMETHYLSALICYLATE

Base Information

• Chemical Name: ETHYL O-CARBOETHOXYMETHYLSALICYLATE
• CAS No.: 56424-77-2
• Molecular Formula: C13H16 O5
• Molecular Weight: 252.267
• Hs Code.: 2918990090
• Mol file: 56424-77-2.mol

Synonyms:o-Anisicacid, a-carboxy-, diethyl ester(6CI,7CI); NSC 406676

Chemical Property of ETHYL O-CARBOETHOXYMETHYLSALICYLATE

Chemical Property:

• Vapor Pressure: 6.39E-05mmHg at 25°C
• Refractive Index: 1.5140
• Boiling Point: 180°C 4mm
• Flash Point: 180°C/4mm
• PSA: 61.83000
• Density: 1.142g/cm³
• LogP: 1.80520

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-2-(ETHOXYCARBONYLMETHOXY)BENZOATE 97.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL O-CARBOETHOXYMETHYLSALICYLATE

There total 6 articles about ETHYL O-CARBOETHOXYMETHYLSALICYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl bromoacetate (105-36-2) + 2-hydroxy-benzoic acid ethyl ester (118-61-6) → ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate (56424-77-2)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 3h;

DOI:10.1021/jm301474t

Reference yield: 35.0%

ethanol (64-17-5) + (2-carboxyphenoxy)acetic acid (635-53-0) → ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate (56424-77-2) + 2-O-(ethoxycarbonylmethyl)benzoic acid (108807-15-4)

Guidance literature:

With phosphorus pentoxide; copper(II) sulfate; sodium sulfate; at 100 ℃; for 4h;

Reference yield:

ethanol (64-17-5) + (2-carboxyphenoxy)acetic acid (635-53-0) → ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate (56424-77-2)

Guidance literature:

With sulfuric acid; benzene;

upstream raw materials:

ethanol

(2-carboxyphenoxy)acetic acid

chloroacetic acid ethyl ester

2-hydroxy-benzoic acid ethyl ester

Downstream raw materials:

2-(2-Ethoxycarbonyl-phenoxy)-essigsaeure-phenylhydrazid

(2-carboxyphenoxy)acetic acid

ethyl 2,3-dihydro-3-oxo-benzofuran-2-carboxylate

Refernces

• 1、 Rackham, Mark D.,Brannigan, James A.,Moss, David K.,Yu, Zhiyong,Wilkinson, Anthony J.,Holder, Anthony A.,Tate, Edward W.,Leatherbarrow, Robin J.. "Discovery of novel and ligand-efficient inhibitors of plasmodium falciparum and plasmodium vivax N-myristoyltransferase". supporting information. p. 371 - 375. Retrieved 2013/02/23.
• 2、 Hadj-esfandiari, Narges,Navidpour, Latifeh,Shadnia, Hooman,Amini, Mohsen,Samadi, Nasrin,Faramarzi, Mohammad Ali,Shafiee, Abbas. "Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2 H)-benzofuranone derivatives". . p. 6354 - 6363. Retrieved 2008/09/21.