N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide

Base Information

• Chemical Name: N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide
• CAS No.: 85815-52-7
• Molecular Formula: C₁₉H₁₆Cl₃N₃O₃
• Molecular Weight: 440.713
• Mol file: 85815-52-7.mol

Synonyms:N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide

Chemical Property of N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide

There total 1 articles about N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N,N-dimethylacetoacetamide (5810-11-7) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide (85815-52-7)

Guidance literature:

With hydrogenchloride; potassium carbonate; sodium nitrite; Yield given. Multistep reaction; 1) aq. acetic acid, 5 deg C, 5 min, 2) r.t., 50 min;

DOI:10.1002/jhet.5570190621

Reference yield: 84.8%

N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide (85815-52-7) → N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide (65698-99-9)

Guidance literature:

With ammonium hydroxide; In ethyl acetate; for 2h; Ambient temperature;

DOI:10.1002/jhet.5570190621

Reference yield:

N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide (85815-52-7) → 2',5-dichloro-2-(3-dimethylcarbamoyl-5-glycylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone (99593-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84.8 percent / aq. ammonia (28percent) / ethyl acetate / 2 h / Ambient temperature

2: 1) THF, hexamethylphosphoramide, r.t., 4 h, 2) acetic acid, reflux, 1.5 h

3: hydrazine hydrate / ethanol / 1 h / Heating

With ammonium hydroxide; hydrazine hydrate; In ethanol; ethyl acetate;

DOI:10.1002/jhet.5570190621

upstream raw materials:

2-chloro-N,N-dimethylacetoacetamide

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

Downstream raw materials:

N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide

2',5-dichloro-2-(3-dimethylcarbamoyl-5-aminomethyl-1H-1,2,4-triazol-1-yl)benzophenone hydrobromide

1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

2',5-dichloro-2-(3-dimethylcarbamoyl-5-phthalylphenylalanylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone