3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

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Chemical Name:3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione
CAS No.:1470408-02-6
Molecular Formula:C₃₃H₃₁BrN₆O₃
Molecular Weight:639.552
Hs Code.:

Synonyms:3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

There total 11 articles about 3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1470408-01-5
3-(1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

: 106-93-4
ethylene dibromide

: 1470408-02-6
3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.07.046

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 1470408-02-6
3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 9 steps

1: hydrazine / ethanol / Reflux

2: 1-nitroisobutane; tetrafluoroboric acid / methanol / 0 - 5 °C

3: phosphinic acid / water / 20 °C

4: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C

5: ethylmagnesium bromide / tetrahydrofuran / -5 - 0 °C

6: lithium chloride; bis(triphenylphosphine)palladium(II) chloride / toluene / 10 h / 100 °C / Inert atmosphere

7: potassium carbonate / N,N-dimethyl-formamide / 10 h / 60 °C

8: hydrogenchloride / water; ethanol / 12 h / 30 - 35 °C

9: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With hydrogenchloride; tetrafluoroboric acid; phosphinic acid; bis(triphenylphosphine)palladium(II) chloride; 1-nitroisobutane; ethylmagnesium bromide; iodine; potassium carbonate; caesium carbonate; lithium chloride; potassium hydroxide; hydrazine; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2013.07.046

Reference yield:

: 63682-46-2
C₆H₄N₅⁽¹⁺⁾*BF₄^(1-)

: 1470408-02-6
3-(1-(2-bromoethyl)-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1: phosphinic acid / water / 20 °C

2: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C

3: ethylmagnesium bromide / tetrahydrofuran / -5 - 0 °C

4: lithium chloride; bis(triphenylphosphine)palladium(II) chloride / toluene / 10 h / 100 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 10 h / 60 °C

6: hydrogenchloride / water; ethanol / 12 h / 30 - 35 °C

7: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With hydrogenchloride; phosphinic acid; bis(triphenylphosphine)palladium(II) chloride; ethylmagnesium bromide; iodine; potassium carbonate; caesium carbonate; lithium chloride; potassium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2013.07.046