6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide

Base Information

Chemical Name:6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide
CAS No.:1258161-40-8
Molecular Formula:C₂₃H₂₃N₃O₂
Molecular Weight:373.455
Hs Code.:

Synonyms:6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide

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Chemical Property of 6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide

Chemical Property:

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Technology Process of 6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide

There total 4 articles about 6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1258161-11-3
6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-(3-methoxyphenyl)nicotinamide

: 74-88-4
methyl iodide

: 1258161-40-8
6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide

Guidance literature:: 6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-(3-methoxyphenyl)nicotinamide; With sodium hydride; In tetrahydrofuran; mineral oil; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 60 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm3014103

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1258161-40-8
6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / Reflux

2.1: triethylamine / dichloromethane / 20 °C

3.1: isopropyl alcohol / 48 h / Reflux

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Inert atmosphere

4.2: 4 h / 60 °C / Inert atmosphere

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; mineral oil;
DOI:10.1021/jm3014103

Reference yield:

: 224817-08-7
6-chloro-N-(3-methoxy-phenyl)-nicotinamide

: 1258161-40-8
6-(3,4-dihydro-1H-isoquinoline-2-yl)-N-methyl-N-(3-methoxyphenyl)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropyl alcohol / 48 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Inert atmosphere

2.2: 4 h / 60 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; isopropyl alcohol; mineral oil;
DOI:10.1021/jm3014103