Technology Process of ethyl m-(bromophenyl)propiolate
There total 4 articles about ethyl m-(bromophenyl)propiolate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-bromophenylacetylene;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
chloroformic acid ethyl ester;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b02452
- Guidance literature:
-
With
copper(l) iodide; potassium carbonate;
dichloro bis(acetonitrile) palladium(II);
In
N,N-dimethyl-formamide;
at 22 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate; methanol / dichloromethane / 6 h / 20 °C
2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 20 °C / Inert atmosphere
With
methanol; n-butyllithium; potassium carbonate; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/acs.orglett.7b02452
