(5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one

Base Information

• Chemical Name: (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one
• CAS No.: 433302-06-8
• Molecular Formula: C₂₆H₃₈N₂O₄Si
• Molecular Weight: 470.684
• Mol file: 433302-06-8.mol

Synonyms:(5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one

Chemical Property of (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one

There total 1 articles about (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (S)-5-((1S,2R)-1,3-Bis-benzyloxy-2-hydroxy-propyl)-pyrazolidin-3-one → (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one (433302-06-8)

Guidance literature:

With 1H-imidazole; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)01195-4

Reference yield: 79.0%

dimethyl acetylenedicarboxylate (762-42-5) + (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one (433302-06-8) → (Z)-2-{(S)-3-[(1S,2R)-1,3-Bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-oxo-pyrazolidin-1-yl}-but-2-enedioic acid dimethyl ester + (3S,5S,1'S,2'R)-3-(1',3'-dibenzyloxy-2'-t-butyldimethylsiloxypropyl)-2,3-dihydro-5,6,7-trimethoxycarbonyl-5-methoxycarbonylmethyl-1H,5H-pyrazolo[1,2-a]pyrazol-1-one

Guidance literature:

With camphor-10-sulfonic acid; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(01)01195-4

Reference yield: 59.0%

dimethyl acetylenedicarboxylate (762-42-5) + 2,2-dimethoxy-propane (77-76-9) + (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one (433302-06-8) → (3S,1'S,2'R)-3-(1',3'-dibenzyloxy-2'-t-butyldimethylsiloxypropyl)-2,3-dihydro-6,7-dimethoxycarbonyl-5,5-dimethyl-1H,5H-pyrazolo[1,2-a]pyrazol-1-one

Guidance literature:

2,2-dimethoxy-propane; (5S,1'S,2'R)-5-(2'-t-butyldimethylsiloxy-1',3'-dibenzyloxy)propyl-pyrazolidin-3-one; With camphor-10-sulfonic acid; In methanol; for 0.5h; Heating;

dimethyl acetylenedicarboxylate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(01)01195-4

upstream raw materials:

tert-butyldimethylsilyl chloride