4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

Base Information

Chemical Name:4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester
CAS No.:243642-03-7
Molecular Formula:C₃₁H₃₈N₂O₆
Molecular Weight:534.653
Hs Code.:

4-(4-{3-[<i>tert</i>-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

Synonyms:4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

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Chemical Property of 4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

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Technology Process of 4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

There total 6 articles about 4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 243641-02-3
ethyl (S)-(-)-4-(4-hydroxyphenyl)-3-phenylbutanoate

: 221901-89-9
2-[N-(3-methanesulfonyloxy-1-propyl)-N-(tert-butoxycarbonyl)amino]pyridine-N-oxide

: 243642-03-7
4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

Guidance literature:: With sodium hydride; In dimethyl sulfoxide;
DOI:10.1016/S0960-894X(03)00102-1

Reference yield:

: 24845-40-7
2-(4-methoxyphenyl)acetophenone

: 243642-03-7
4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / LiN(TMS)2 / tetrahydrofuran

2.1: Et₃Si; BF₃*OEt₂ / CH₂Cl₂

2.2: 91 percent / H₂ / 10 percent Pd/C / ethanol

3.1: EtSH; AlCl₃ / CH₂Cl₂

4.1: 38 percent / NaH / dimethylsulfoxide

With triethylsilane; aluminium trichloride; boron trifluoride diethyl etherate; sodium hydride; ethanethiol; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 3.2: chiral HPLC resolution;
DOI:10.1016/S0960-894X(03)00102-1

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 243642-03-7
4-(4-{3-[tert-butoxycarbonyl-(1-oxy-pyridin-2-yl)-amino]-propoxy}-phenyl)-3-phenyl-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / 2-methyl-propan-2-ol

2: 64 percent / pyridine / CHCl₃

3: 38 percent / NaH / dimethylsulfoxide

With pyridine; sodium hydride; In chloroform; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1016/S0960-894X(03)00102-1