3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Base Information

Chemical Name:3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide
CAS No.:1192021-13-8
Molecular Formula:C₁₈H₁₈F₃N₃O₄
Molecular Weight:397.354
Hs Code.:

Synonyms:3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

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Chemical Property of 3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Chemical Property:

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Technology Process of 3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

There total 3 articles about 3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 454-81-9
2-amino-4-(trifluoromethyl)phenol

: 179024-65-8
3-tert-butoxycarbonylaminoisonicotinic acid

: 1192021-13-8
3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Guidance literature:: 3-tert-butoxycarbonylaminoisonicotinic acid; With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 0.25h;

2-amino-4-(trifluoromethyl)phenol; at 60 ℃; for 2h;

Reference yield:

: 59-67-6
nicotinic acid

: 1192021-13-8
3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 20 °C

1.2: 6 h / 80 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -60 - 0 °C

2.2: 2 h / 20 °C / Cooling with acetone-dry ice

2.3: pH ~ 3

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 0.25 h / 20 °C

3.2: 2 h / 60 °C

With pyridine; n-butyllithium; diphenyl phosphoryl azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; toluene;

Reference yield:

: 56700-70-0
3-(tert-butoxycarbonylamino)pyridine

: 1192021-13-8
3-tert-butoxycarbonylamino-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -60 - 0 °C

1.2: 2 h / 20 °C / Cooling with acetone-dry ice

1.3: pH ~ 3

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 0.25 h / 20 °C

2.2: 2 h / 60 °C

With pyridine; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; hexane;