(1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

Base Information

• Chemical Name: (1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate
• CAS No.: 308245-23-0
• Molecular Formula: C₂₁H₂₂N₂O₇S
• Molecular Weight: 446.481
• Mol file: 308245-23-0.mol

Synonyms:(1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

Chemical Property of (1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate

There total 3 articles about (1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + N-[(1S,2S)-2-Hydroxy-1-hydroxymethyl-2-(4-methylsulfanyl-phenyl)-ethyl]-2-nitro-benzamide → (1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate (308245-23-0)

Guidance literature:

With pyridine; dmap; at 60 ℃; for 3h;

DOI:10.1021/ja001225c

Reference yield:

(1S,2S)-(+)-thiomicamine (16854-32-3) → (1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate (308245-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP; pyridine / 0 °C

2: pyridine; DMAP / 3 h / 60 °C

With pyridine; dmap;

DOI:10.1021/ja001225c

Reference yield:

2-nitrobenzyl chloride (610-14-0) → (1S,2S)-2-(2-nitrobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate (308245-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP; pyridine / 0 °C

2: pyridine; DMAP / 3 h / 60 °C

With pyridine; dmap;

DOI:10.1021/ja001225c

upstream raw materials:

acetic anhydride

(1S,2S)-(+)-thiomicamine

2-nitrobenzyl chloride

Downstream raw materials:

4-amino-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediyl-bisacetate)carbamoylphenyl)carbamoyl]pyridine

4-chloro-2,6-bis[((2-(1S,2S)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate)carbamoylphenyl)carbamoyl]pyridine

(1S,2S)-2-(2-aminobenzamido)-1-(4-methylthiophenyl)-1,3-propanediylbisacetate