3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione

Base Information

• Chemical Name: 3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione
• CAS No.: 1318252-73-1
• Molecular Formula: C₂₀H₁₆N₄O₂S
• Molecular Weight: 376.439

Synonyms:3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione

Chemical Property of 3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione

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Technology Process of 3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione

There total 3 articles about 3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-Aminocrotononitrile (1118-61-2) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + mercaptoacetic acid (68-11-1) + phenylhydrazine (100-63-0) → 3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione (1318252-73-1)

Guidance literature:

With nano n-propylsulfonated γ-Al₂O₃; In water; for 5.16667h; Solvent; Temperature; Time; Reagent/catalyst; Concentration; Reflux; Green chemistry;

DOI:10.1002/aoc.2942

Reference yield: 89.0%

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + mercaptoacetic acid (68-11-1) → 3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione (1318252-73-1)

Guidance literature:

With bioglycerol-based sulfonic acid functionalized carbon catalyst; In acetonitrile; at 75 - 80 ℃; for 7h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.04.122

Reference yield:

3-(5-amino-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydroxyindolin-2-one (380471-69-2) + mercaptoacetic acid (68-11-1) → 3'-methyl-1'-phenyl-6',8'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-e][1,4]thiazepine]-2,7'(1'H)-dione (1318252-73-1)

Guidance literature:

With toluene-4-sulfonic acid; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1016/j.tet.2011.05.069

upstream raw materials:

3-(5-amino-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydroxyindolin-2-one

mercaptoacetic acid

1-Phenyl-3-methyl-5-aminopyrazole

indole-2,3-dione

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