<2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

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Chemical Name:<2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide
CAS No.:89578-76-7
Molecular Formula:C₃₄H₆₁N₃O₅SSi
Molecular Weight:652.027
Hs Code.:

<2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

Synonyms:<2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

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Chemical Property of <2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

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Technology Process of <2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

There total 20 articles about <2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 13325-10-5
4-Aminobutanol

: 89578-83-6
{(2R,6S)-6-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-acetic acid 2,4,5-trichloro-phenyl ester

: 89578-76-7
<2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

Guidance literature:: In N,N-dimethyl-formamide; at -20 ℃; for 18h;
DOI:10.1021/ja00323a030

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 89578-76-7
<2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C

2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature

4: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h

5: 82 percent / dimethylformamide / 18 h / -20 °C

With pyridine; lithium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00323a030

Reference yield:

: 72952-73-9
(E)-2,4-pentadienyltrimethylsilane

: 89578-76-7
<2α,6β(S*)>-N-(4-hydroxybutyl)-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

Guidance literature:: Multi-step reaction with 16 steps

1: 69 percent / TiCl₄ / CH₂Cl₂ / -41 °C

2: 95 percent / trifluoroacetic acid / 24 h

3: 82 percent / acetone / 72 h / Heating

4: 97 percent / pyridine / 12 h

5: 83 percent / diisopropyl-ethylamine / toluene / 3 h / 215 °C

6: 96 percent / 5percent NaOH / methanol / 2 h / Ambient temperature

7: oxalyl chloride / toluene / 3 h / Ambient temperature

8: diethyl ether / 1 h / Ambient temperature

9: Ag₂O / 12 h

10: Ba(OH)2*8H₂O / various solvent(s); H₂O / 48 h / Heating

11: SOCl₂ / 12 h / Heating

12: 91 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / 0 °C

13: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

14: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature

15: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h

16: 82 percent / dimethylformamide / 18 h / -20 °C

With 2,6-dimethylpyridine; barium dihydroxide; lithium hydroxide; sodium hydroxide; thionyl chloride; oxalyl dichloride; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In pyridine; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; trifluoroacetic acid;
DOI:10.1021/ja00323a030