7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester

Base Information

Chemical Name:7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester
CAS No.:884506-35-8
Molecular Formula:C₂₈H₃₀O₈
Molecular Weight:494.541
Hs Code.:

Synonyms:7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester

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Chemical Property of 7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester

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Technology Process of 7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester

There total 3 articles about 7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 52328-98-0,917813-54-8
O,O-dimethyl-curcumin

: 623-47-2
propynoic acid ethyl ester

: 884506-35-8
7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester

Guidance literature:: O,O-dimethyl-curcumin; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

propynoic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2005.11.034

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 884506-35-8
7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: boric anhydride / ethyl acetate / 0.5 h / 40 °C

1.2: tributyl borate; butylamine / ethyl acetate / 24 h / 40 °C

1.3: hydrochloric acid / ethyl acetate / 0.5 h / 60 °C

2.1: sodium hydride / tetrahydrofuran / 2.5 h / 0 - 20 °C

2.2: 54 percent / tetrahydrofuran / 2 h / 20 °C

With boron trioxide; sodium hydride; In tetrahydrofuran; ethyl acetate; 2.2: Michael addition;
DOI:10.1016/j.bmc.2005.11.034

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 884506-35-8
7-(3,4-dimethoxyphenyl)-4-[3-(3,4-dimethoxyphenyl)-acryloyl]-5-hydroxy-hepta-2,4,6-trienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: boric anhydride / ethyl acetate / 0.5 h / 40 °C

1.2: tributyl borate; butylamine / ethyl acetate / 24 h / 40 °C

1.3: hydrochloric acid / ethyl acetate / 0.5 h / 60 °C

2.1: sodium hydride / tetrahydrofuran / 2.5 h / 0 - 20 °C

2.2: 54 percent / tetrahydrofuran / 2 h / 20 °C

With boron trioxide; sodium hydride; In tetrahydrofuran; ethyl acetate; 2.2: Michael addition;
DOI:10.1016/j.bmc.2005.11.034