tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate

Base Information

• Chemical Name: tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate
• CAS No.: 1085928-20-6
• Molecular Formula: C₁₉H₃₁N₃O₃
• Molecular Weight: 349.473
• Mol file: 1085928-20-6.mol

Synonyms:tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate

Chemical Property of tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate

There total 3 articles about tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 3-bromopropylamine tert-butylcarbamate (83948-53-2) → tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate (1085928-20-6)

Guidance literature:

1-(2-Methoxyphenyl)piperazine; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.0333333h; Inert atmosphere;

3-bromopropylamine tert-butylcarbamate; With sodium iodide; In acetonitrile; for 24h; Inert atmosphere; Reflux;

DOI:10.1021/jm500457x

Reference yield: 57.0%

1-(2-methoxyphenyl)piperazine hydrochloride (5464-78-8) + O-tosyl-3-tert-butoxycarbonylamino-1-propanol (80909-96-2) → tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate (1085928-20-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 12h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate (1085928-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 0.5 h / 20 °C

2: sodium iodide / dichloromethane / 5 h / 20 °C

With dmap; triethylamine; sodium iodide; In dichloromethane;

DOI:10.1016/j.ejmech.2015.04.005

upstream raw materials:

1-(2-methoxyphenyl)piperazine hydrochloride

O-tosyl-3-tert-butoxycarbonylamino-1-propanol

1-(2-Methoxyphenyl)piperazine

3-bromopropylamine tert-butylcarbamate

Downstream raw materials:

3-amino-5-chloro-6-methoxy-N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

3-(4-(2-methoxyphenyl)piperazin-1-yl)propylamine