Boc-MOM-Met-OBn

Base Information

• Chemical Name: Boc-MOM-Met-OBn
• CAS No.: 1421429-23-3
• Molecular Formula: C₁₉H₂₉NO₅S
• Molecular Weight: 383.509
• Mol file: 1421429-23-3.mol

Synonyms:Boc-MOM-Met-OBn

Chemical Property of Boc-MOM-Met-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-MOM-Met-OBn

There total 1 articles about Boc-MOM-Met-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-tert-butoxycarbonyl-L-methionine benzyl ester (87746-57-4) → Boc-MOM-Met-OBn (1421429-23-3)

Guidance literature:

formaldehyd; N-tert-butoxycarbonyl-L-methionine benzyl ester; With chloro-trimethyl-silane; magnesium sulfate; In dichloromethane; at 0 - 20 ℃; for 12h;

methanol; With triethylamine; In dichloromethane; at 0 ℃; for 5h;

DOI:10.1021/ol303568f

Reference yield:

Boc-MOM-Met-OBn (1421429-23-3) → benzyl N-(tert-butoxycarbonyl)-N-(methoxymethyl)-L-methionine-α-d

Guidance literature:

Boc-MOM-Met-OBn; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

With water-d2; In tetrahydrofuran; toluene; at -78 ℃; for 0.25h; Inert atmosphere;

With deuteroacetic acid; In tetrahydrofuran; toluene; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.02.012

Reference yield:

Boc-MOM-Met-OBn (1421429-23-3) → C12H16(2)HNO2S

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.25 h / -78 °C / Inert atmosphere

1.3: -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; potassium hexamethylsilazane; In tetrahydrofuran; ethyl acetate; toluene;

DOI:10.1016/j.tetlet.2018.02.012

upstream raw materials:

methanol

formaldehyd

N-tert-butoxycarbonyl-L-methionine benzyl ester