(1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

Base Information

Chemical Name:(1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine
CAS No.:1409944-17-7
Molecular Formula:C₁₅H₁₅BrF₂N₂S
Molecular Weight:373.264
Hs Code.:

Synonyms:(1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

Chemical Property:

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Technology Process of (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

There total 14 articles about (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1409944-06-4
(R)-N-((1S,2S)-1-(3-bromopyrazin-2-yl)-2-(2,3-difluorophenyl)hex-5-enyl)-2-methylpropane-2-sulfinamide

: 1409944-17-7
(1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

Guidance literature:: With hydrogenchloride; In methanol; diethyel ether; at 20 ℃; for 2.5h;

Reference yield:

: 2100-17-6
4-pentenal

: 1409944-17-7
(1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N',N'-tetramethylguanidine / toluene / 1 h / 0 °C

1.2: 2 h / 20 °C

2.1: water / 1,4-dioxane

2.2: 14.03 h / 20 - 35 °C / Inert atmosphere

3.1: sodium methylate / methanol / 0.5 h / 0 °C / Inert atmosphere

3.2: 4 h / -60 - -20 °C

3.3: 18 h / 20 °C

4.1: titanium(IV) tetraethanolate / benzene; tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

5.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

5.2: 2 h / -75 °C

6.1: hydrogenchloride / methanol; diethyel ether / 2.5 h / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium methylate; lithium diisopropyl amide; N,N,N',N'-tetramethylguanidine; titanium(IV) tetraethanolate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyel ether; toluene; benzene;

Reference yield:

: 1409944-03-1
(S)-1,2-difluoro-3-(1-nitrohex-5-en-2-yl)benzene

: 1409944-17-7
(1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / -60 - -20 °C

1.3: 18 h / 20 °C

2.1: titanium(IV) tetraethanolate / benzene; tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

3.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3.2: 2 h / -75 °C

4.1: hydrogenchloride / methanol; diethyel ether / 2.5 h / 20 °C

With hydrogenchloride; n-butyllithium; sodium methylate; lithium diisopropyl amide; titanium(IV) tetraethanolate; In tetrahydrofuran; methanol; diethyel ether; benzene;