tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate

Base Information

Chemical Name:tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate
CAS No.:1409944-19-9
Molecular Formula:C₂₀H₂₃BrF₂N₂O₂S
Molecular Weight:473.382
Hs Code.:

Synonyms:tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate

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Chemical Property of tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate

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Technology Process of tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate

There total 8 articles about tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1409944-17-7
(1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-en-1-amine

: 1409944-19-9
tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 2100-17-6
4-pentenal

: 1409944-19-9
tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N,N',N'-tetramethylguanidine / toluene / 1 h / 0 °C

1.2: 2 h / 20 °C

2.1: water / 1,4-dioxane

2.2: 14.03 h / 20 - 35 °C / Inert atmosphere

3.1: sodium methylate / methanol / 0.5 h / 0 °C / Inert atmosphere

3.2: 4 h / -60 - -20 °C

3.3: 18 h / 20 °C

4.1: titanium(IV) tetraethanolate / benzene; tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

5.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

5.2: 2 h / -75 °C

6.1: hydrogenchloride / methanol; diethyel ether / 2.5 h / 20 °C

7.1: dichloromethane / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium methylate; lithium diisopropyl amide; N,N,N',N'-tetramethylguanidine; titanium(IV) tetraethanolate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; diethyel ether; toluene; benzene;

Reference yield:

: 1409944-03-1
(S)-1,2-difluoro-3-(1-nitrohex-5-en-2-yl)benzene

: 1409944-19-9
tert-butyl (1S,2S)-1-(4-bromothiazol-5-yl)-2-(2,3-difluorophenyl)hex-5-enylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / -60 - -20 °C

1.3: 18 h / 20 °C

2.1: titanium(IV) tetraethanolate / benzene; tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

3.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3.2: 2 h / -75 °C

4.1: hydrogenchloride / methanol; diethyel ether / 2.5 h / 20 °C

5.1: dichloromethane / 20 °C

With hydrogenchloride; n-butyllithium; sodium methylate; lithium diisopropyl amide; titanium(IV) tetraethanolate; In tetrahydrofuran; methanol; dichloromethane; diethyel ether; benzene;