(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate

Base Information

Chemical Name:(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate
CAS No.:714273-67-3
Molecular Formula:C₂HF₃O₂*C₁₉H₁₈F₂N₄O₂
Molecular Weight:486.398
Hs Code.:

Synonyms:(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate

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Chemical Property of (3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate

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Technology Process of (3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate

There total 7 articles about (3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 714273-84-4
1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

: 2646-90-4
2,5-difluorobenzaldehyde

: 76-05-1
trifluoroacetic acid

: 714273-67-3
(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate

Guidance literature:: 1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione; 2,5-difluorobenzaldehyde; With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile; Inert atmosphere;
DOI:10.1021/jm2009088

Reference yield:

: 714273-83-3
5-(tert-butyl)-1H-imidazole-4-carbaldehyde

: 714273-67-3
(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2.2: Inert atmosphere

With caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm2009088

Reference yield:

: 714273-89-9
5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester

: 714273-67-3
(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 14 h / 165 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: manganese(IV) oxide / acetone / 2 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

5.2: Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm2009088