benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate

Base Information

• Chemical Name: benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate
• CAS No.: 172833-41-9
• Molecular Formula: C₂₁H₃₃N₃O₆
• Molecular Weight: 423.51

Synonyms:benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate

Chemical Property of benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate

Chemical Property:

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Technology Process of benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate

There total 4 articles about benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Z-Lys(Boc)-OH (2389-60-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate (172833-41-9)

Guidance literature:

Z-Lys(Boc)-OH; With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; for 3h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01880

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) + N,0-dimethylhydroxylamine (1117-97-1) → benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate (172833-41-9)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2006.04.013

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate (172833-41-9)

Guidance literature:

Multi-step reaction with 2 steps

2: TEA

With TEA;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

Z-Lys(Boc)-OH

N,0-dimethylhydroxylamine

Downstream raw materials:

(5-benzyloxycarbonylamino-6-hydroxy-6-{5-[4-(4-phenyl-butyl)-piperazin-1-ylmethyl]-[1,2,4]oxadiazol-3-yl}-hexyl)-carbamic acid tert-butyl ester

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