5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one

Base Information

Chemical Name:5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one
CAS No.:1229017-74-6
Molecular Formula:C₂₂H₃₀BrN₃O₇
Molecular Weight:528.4
Hs Code.:

Synonyms:5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one

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Chemical Property of 5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one

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Technology Process of 5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one

There total 7 articles about 5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 50-99-7
D-glucose

: 2-(5-amino-2-propoxyphenyl)-5-bromo-6-isopropylpyrimidin-4(3H)-one hydrochloride

: 1229017-74-6
5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one

Guidance literature:: With acetic acid; In butan-1-ol; for 12h; Inert atmosphere; Reflux;

Reference yield: 21.0%

: 2280-44-6
D-Glucose

: 2-(5-amino-2-propoxyphenyl)-5-bromo-6-isopropylpyrimidin-4(3H)-one hydrochloride

: 1229017-74-6
5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one

Guidance literature:: With acetic acid; In butan-1-ol; for 12h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.06.062

Reference yield:

: 1229019-44-6
5-bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one

: 1229017-74-6
5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / water / 3 h / 20 °C

2: hydrogenchloride; iron / water / 1 h / 100 °C / Reflux

3: acetic acid / butan-1-ol / 12 h / Reflux; Inert atmosphere

With hydrogenchloride; sulfuric acid; nitric acid; iron; acetic acid; In water; butan-1-ol;
DOI:10.1016/j.bmcl.2013.06.062