α,α,α-iodinefluoroacetophenone

Base Information

• Chemical Name: α,α,α-iodinefluoroacetophenone
• CAS No.: 150542-06-6
• Molecular Formula: C₈H₅F₂IO
• Molecular Weight: 282.028
• Mol file: 150542-06-6.mol

Synonyms:α,α,α-iodinefluoroacetophenone

Chemical Property of α,α,α-iodinefluoroacetophenone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α,α-iodinefluoroacetophenone

There total 6 articles about α,α,α-iodinefluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene (86340-78-5) → 2,2-difluoro-1-phenylethanone (395-01-7) + α,α,α-iodinefluoroacetophenone (150542-06-6)

Guidance literature:

With iodine; In various solvent(s); for 5h; Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo00122a044

Reference yield: 60.0%

2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one (1259998-89-4) → α,α,α-iodinefluoroacetophenone (150542-06-6)

Guidance literature:

2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one; With iodine; lithium bromide; In tetrahydrofuran; for 0.166667h;

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

4,4,4-trifluoro-3-hydroxy-1-phenylbut-2-en-1-one (41463-86-9) → α,α,α-iodinefluoroacetophenone (150542-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Selectfluor / acetonitrile

2: lithium bromide; iodine / tetrahydrofuran

With iodine; Selectfluor; lithium bromide; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.cclet.2015.07.007

upstream raw materials:

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene

2-chloro-2,2-difluoroacetophenone

2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one

4,4,4-trifluoro-3-hydroxy-1-phenylbut-2-en-1-one

Downstream raw materials:

1,1-Difluoro-3-iodooctyl phenyl ketone

phenyl α,α-difluoro-γ-iodoheptyl ketone

2,2-Difluoro-4-iodo-1-phenyl-1,7-octanedione

N,N-Dimethyl-4-benzoyl-4,4-difluoro-2-iodobutanamide