7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one

Base Information

• Chemical Name: 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one
• CAS No.: 1642784-52-8
• Molecular Formula: C₃₇H₃₀O₆
• Molecular Weight: 570.642
• Mol file: 1642784-52-8.mol

Synonyms:7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one

Chemical Property of 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one

There total 4 articles about 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

7,8-bis(benzyloxy)-2-oxo-2H-chromen-4-yl trifluoromethanesulfonate (1642785-09-8) + (3-(benzyloxy)-4-methoxyphenyl)boronic acid (243990-54-7) → 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one (1642784-52-8)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 120 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1038/aps.2014.33

Reference yield:

1-(3,4-bis(benzyloxy)-2-hydroxyphenyl)ethanone (2652-27-9) → 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one (1642784-52-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium / 0.33 h / 120 °C

2: acetic acid / 6 h / Reflux

3: triethylamine / dichloromethane / 12 h / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; sodium carbonate / 1,4-dioxane / 0.33 h / 120 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium; sodium carbonate; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; 4: |Suzuki Coupling;

DOI:10.1038/aps.2014.33

Reference yield:

ethyl 3-(3,4-bis(benzyloxy)phenyl)-3-oxopropanoate (1643318-41-5) → 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one (1642784-52-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 6 h / Reflux

2: triethylamine / dichloromethane / 12 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; sodium carbonate / 1,4-dioxane / 0.33 h / 120 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; 3: |Suzuki Coupling;

DOI:10.1038/aps.2014.33

upstream raw materials:

7,8-bis(benzyloxy)-2-oxo-2H-chromen-4-yl trifluoromethanesulfonate

(3-(benzyloxy)-4-methoxyphenyl)boronic acid

ethyl 3-(3,4-bis(benzyloxy)phenyl)-3-oxopropanoate

7,8-bis(benzyloxy)-4-hydroxy-2H-chromen-2-one

Downstream raw materials:

7,8-dihydroxy-4-(3-hydroxy-4-methoxyphenyl)-3,4-dihydrocoumarin