2652-27-9

Basic information

• Product Name: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-
• CAS NO: 2652-27-9
• Molecular Formula: C22H20O4
• Molecular Weight: 348.398
• Mol File: 2652-27-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-(2652-27-9)
• EPA Substance Registry System: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-(2652-27-9)

Safety Data

• Hazardous Substances Data: 2652-27-9(Hazardous Substances Data)

Usage

General Description

"Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-" is a chemical compound that belongs to the family of ethanones. It is also known by its Chemical Abstracts Service (CAS) number 72968-58-4. Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]- is characterized by its structure, which includes a ketone group attached to a phenyl ring, as well as hydroxyl and methoxy groups connected to another phenyl ring. It is used in the pharmaceutical and chemical industries for various purposes, including as an intermediate in the synthesis of other compounds. It is important to handle this chemical with care and to follow safety guidelines when working with it in laboratory or industrial settings.

Upstream product

• 100-39-0 benzyl bromide 
• 87-66-1 2-hydroxyresorcinol 
• 50439-63-9 1-(2,3,4-tris(benzyloxy)phenyl)ethanone 
• 528-21-2 2',3',4'-trihydroxyacetophenone 
• 100-44-7 benzyl chloride 
• 1024-41-5 benzyl tosylate 

Downstream Products

• 79492-65-2 2-(3',4',5'-trimethoxy)benzoyloxy-3,4-dibenzyloxyacetophenone 
• 1196971-28-4 (E)-3',4'-dibenzyloxy-2'-(3,4-dimethoxycinnamoyloxy)acetophenone 
• 2652-28-0 3',4',4-Tribenzyloxy-2'-hydroxy-chalkon 
• 786706-00-1 7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one 
• 786706-01-2 7,8-bis-(1,1-dimethyl-allyloxy)-2-phenyl-4H-chromen-4-one 
• 500866-00-2 C₂₉H₂₂O₄ 
• 1377187-73-9 C₃₆H₂₈O₅ 
• 1033873-86-7 C₂₅H₂₆O₄ 
• 38183-03-8 7,8-dihydroxyflavone 
• 147711-26-0 7,8,4'-Trihydroxyflavone 
• 93827-33-9 C₂₉H₂₄O₄ 
• 1610522-93-4 7,8-bis(benzyloxy)-4-hydroxy-2H-chromen-2-one 
• 1643318-41-5 ethyl 3-(3,4-bis(benzyloxy)phenyl)-3-oxopropanoate 
• 1642785-09-8 7,8-bis(benzyloxy)-2-oxo-2H-chromen-4-yl trifluoromethanesulfonate 

Relevant articles and documents

Preparation method of 7,8-dihydroxy flavone

The invention relates to a preparation method of 7,8-dihydroxy flavone, and belongs to the technical field of synthesis of medical intermediates. The preparation method comprises the following steps:by taking pyrogallol as a raw material, introducing an acetyl group to synthesize DHF1; protecting three phenolic hydroxyl groups to synthesize DHF2; selectively reducing the ortho-hydroxyl group of the acetyl group to synthesize DHF3; carrying out an aldol condensation reaction on DHF3 and benzaldehyde to prepare DHF4; carrying out a cyclization reaction under the condition of iodine catalysis toobtain DHF5; and finally carrying out a hydrolysis reaction to generate the final product. The method is simple and convenient to operate, reasonable in reaction process, low in production cost, goodin product quality, free of environmental pollution and suitable for industrial production, wherein the content of the product is higher than 98%.

Design and synthesis of 3,3′-biscoumarin-based c-Met inhibitors

A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3′-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of coumarin derivatives. Among these compounds, 38 and 40 not only showed potent enzyme activities with IC50 values of 107 nM and 30 nM, respectively, but also inhibited c-Met phosphorylation in BaF3/TPR-Met and EBC-1 cells. This journal is the Partner Organisations 2014.

Effects of electron-withdrawing substituents on DPPH radical scavenging reactions of protocatechuic acid and its analogues in alcoholic solvents

The DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity of protocatechuic acid (3,4-dihydroxybenzoic acid) and its related catechols was examined. Compounds possessing strong electron-withdrawing substituents showed high activity. NMR analysis of the reaction mixtures of catechols and DPPH radical in methanol showed the formation of methanol adducts. The results suggest that high radical scavenging activity of catechols in alcohol is due to a nucleophilic addition of an alcohol molecule on o-quinones, which leads to a regeneration of a catechol structure. Furthermore, the radical scavenging activity in alcohols would largely depend on the electron-withdrawing/donating substituents, since they affect the susceptibility toward nucleophilic attacks on o-quinone.